The contributions of oxytocin and vasopressin pathway genes to human behavior

Richard P. Ebstein; Ariel Knafo; David Mankuta; Soo Hong Chew; Poh San Lai

doi:10.1016/j.yhbeh.2011.12.014

The contributions of oxytocin and vasopressin pathway genes to human behavior

Richard P. Ebstein^*, Ariel Knafo, David Mankuta, Soo Hong Chew, Poh San Lai

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

232 Scopus citations

Abstract

Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans. There is intense interest in how these simple nonapeptides mediate normal and abnormal behavior, especially regarding disorders of the social brain such as autism that are characterized by deficits in social communication and social skills. The current review examines in detail the behavioral genetics of the first level of human AVP-OXT pathway genes including arginine vasopressin 1a receptor (. AVPR1a), oxytocin receptor (. OXTR), . AVP (. AVP-neurophysin II [NPII]) and . OXT (. OXT neurophysin I [NPI]), oxytocinase/vasopressinase (. LNPEP), ADP-ribosyl cyclase (. CD38) and arginine vasopressin 1b receptor (. AVPR1b). Wherever possible we discuss evidence from a variety of research tracks including molecular genetics, imaging genomics, pharmacology and endocrinology that support the conclusions drawn from association studies of social phenotypes and detail how common polymorphisms in AVP-OXT pathway genes contribute to the behavioral hard wiring that enables individual . Homo sapiens to interact successfully with conspecifics. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

Original language	English
Pages (from-to)	359-379
Number of pages	21
Journal	Hormones and Behavior
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/j.yhbeh.2011.12.014
State	Published - Mar 2012

Bibliographical note

Funding Information:
Financial support from the National University of Singapore (Decision Making Under Urbanization: A Neurobiological and Experimental Economics Approach), Ministry of Education at Singapore (Biological Economics and Decision Making), the AXA Research Foundation (Biology of Decision Making under Risk) and the Templeton Foundation (Genes, God and Generosity: The Yin Yang of DNA and Culture), is gratefully acknowledged.

Keywords

ADP-ribosyl cyclase (CD38)
Arginine receptor 1b receptor (AVPR1b)
Arginine vasopressin 1a receptor (AVPR1a)
LNPEP (oxytocinase)
Neurophysin
Oxytocin
Oxytocin receptor (OXTR)
Plasma oxytocin
Polymorphism
Vasopressin

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10.1016/j.yhbeh.2011.12.014

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title = "The contributions of oxytocin and vasopressin pathway genes to human behavior",

abstract = "Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans. There is intense interest in how these simple nonapeptides mediate normal and abnormal behavior, especially regarding disorders of the social brain such as autism that are characterized by deficits in social communication and social skills. The current review examines in detail the behavioral genetics of the first level of human AVP-OXT pathway genes including arginine vasopressin 1a receptor (. AVPR1a), oxytocin receptor (. OXTR), . AVP (. AVP-neurophysin II [NPII]) and . OXT (. OXT neurophysin I [NPI]), oxytocinase/vasopressinase (. LNPEP), ADP-ribosyl cyclase (. CD38) and arginine vasopressin 1b receptor (. AVPR1b). Wherever possible we discuss evidence from a variety of research tracks including molecular genetics, imaging genomics, pharmacology and endocrinology that support the conclusions drawn from association studies of social phenotypes and detail how common polymorphisms in AVP-OXT pathway genes contribute to the behavioral hard wiring that enables individual . Homo sapiens to interact successfully with conspecifics. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.",

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author = "Ebstein, {Richard P.} and Ariel Knafo and David Mankuta and Chew, {Soo Hong} and Lai, {Poh San}",

note = "Funding Information: Financial support from the National University of Singapore (Decision Making Under Urbanization: A Neurobiological and Experimental Economics Approach), Ministry of Education at Singapore (Biological Economics and Decision Making), the AXA Research Foundation (Biology of Decision Making under Risk) and the Templeton Foundation (Genes, God and Generosity: The Yin Yang of DNA and Culture), is gratefully acknowledged.",

year = "2012",

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doi = "10.1016/j.yhbeh.2011.12.014",

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AU - Lai, Poh San

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JO - Hormones and Behavior

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The contributions of oxytocin and vasopressin pathway genes to human behavior

Abstract

Bibliographical note

Keywords

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