The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease

Esti Davidovich; Miriam Davidovits; Benny Peretz; Joseph Shapira; Doron J. Aframian

doi:10.1093/ndt/gfp101

The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease

Esti Davidovich, Miriam Davidovits, Benny Peretz, Joseph Shapira, Doron J. Aframian

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background. Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports have described abundant dental calculus formation in children suffering from chronic kidney disease (CKD). Moreover, dental calculus scores (DCS) and their correlation with renal disease severity have not been studied.Methods. DCS in 74 young CKD patients were evaluated: 25 pre-dialytic (PrD), 18 on dialysis (D) and 31 with transplants (T) compared to 32 healthy participants (C). Saliva and serum analysis included creatinine (Cr), urea (U), calcium (Ca), phosphorous (P), magnesium (Mg) as well as intraoral pH levels.Results. All patient groups presented high DCS. DCS and pH levels were higher in the D group with a positive correlation between pH and lower incisor DCS (r = 0.56, P = 0.017). The highest salivary Ca was found in the PrD group. Salivary P in the PrD group was found to be higher than in the T and C groups. The lowest salivary Mg was found in the D group while the highest salivary Ca×P product was found in the PrD group. In all patient groups, salivary U was higher than in the C group with a 2.5-fold increase in the D group. Salivary Cr resembled the U salivary concentrations.Conclusions. Alterations in salivary Ca, P, Mg, U, Cr and intraoral pH levels were observed in the patient groups. DCS correlated with renal disease severity and therefore may be a reflection of other tissue calcification pathologies found in these patients.

Original language	English
Pages (from-to)	2439-2445
Number of pages	7
Journal	Nephrology Dialysis Transplantation
Volume	24
Issue number	8
DOIs	https://doi.org/10.1093/ndt/gfp101
State	Published - Aug 2009

Bibliographical note

Funding Information:
Acknowledgements. This study was sponsored by the Israeli Ministry of Health, grant no. 3-6396. We thank Mrs Shlomit Gan for her statistical work for this manuscript and Dr Ruth Tor for her assistance. Partial data from this manuscript were presented as an abstract in the IADR 2007 Thessaloniki conference.

Keywords

Ca × P product
Chronic kidney disease
Dental calculus
Saliva
Vascular calcifications

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ndt/gfp101

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@article{cd5959b108b640f6a99939fe5b570694,

title = "The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease",

abstract = "Background. Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports have described abundant dental calculus formation in children suffering from chronic kidney disease (CKD). Moreover, dental calculus scores (DCS) and their correlation with renal disease severity have not been studied.Methods. DCS in 74 young CKD patients were evaluated: 25 pre-dialytic (PrD), 18 on dialysis (D) and 31 with transplants (T) compared to 32 healthy participants (C). Saliva and serum analysis included creatinine (Cr), urea (U), calcium (Ca), phosphorous (P), magnesium (Mg) as well as intraoral pH levels.Results. All patient groups presented high DCS. DCS and pH levels were higher in the D group with a positive correlation between pH and lower incisor DCS (r = 0.56, P = 0.017). The highest salivary Ca was found in the PrD group. Salivary P in the PrD group was found to be higher than in the T and C groups. The lowest salivary Mg was found in the D group while the highest salivary Ca×P product was found in the PrD group. In all patient groups, salivary U was higher than in the C group with a 2.5-fold increase in the D group. Salivary Cr resembled the U salivary concentrations.Conclusions. Alterations in salivary Ca, P, Mg, U, Cr and intraoral pH levels were observed in the patient groups. DCS correlated with renal disease severity and therefore may be a reflection of other tissue calcification pathologies found in these patients.",

keywords = "Ca × P product, Chronic kidney disease, Dental calculus, Saliva, Vascular calcifications",

author = "Esti Davidovich and Miriam Davidovits and Benny Peretz and Joseph Shapira and Aframian, {Doron J.}",

note = "Funding Information: Acknowledgements. This study was sponsored by the Israeli Ministry of Health, grant no. 3-6396. We thank Mrs Shlomit Gan for her statistical work for this manuscript and Dr Ruth Tor for her assistance. Partial data from this manuscript were presented as an abstract in the IADR 2007 Thessaloniki conference.",

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doi = "10.1093/ndt/gfp101",

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T1 - The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease

AU - Davidovich, Esti

AU - Davidovits, Miriam

AU - Peretz, Benny

AU - Shapira, Joseph

AU - Aframian, Doron J.

N1 - Funding Information: Acknowledgements. This study was sponsored by the Israeli Ministry of Health, grant no. 3-6396. We thank Mrs Shlomit Gan for her statistical work for this manuscript and Dr Ruth Tor for her assistance. Partial data from this manuscript were presented as an abstract in the IADR 2007 Thessaloniki conference.

PY - 2009/8

Y1 - 2009/8

N2 - Background. Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports have described abundant dental calculus formation in children suffering from chronic kidney disease (CKD). Moreover, dental calculus scores (DCS) and their correlation with renal disease severity have not been studied.Methods. DCS in 74 young CKD patients were evaluated: 25 pre-dialytic (PrD), 18 on dialysis (D) and 31 with transplants (T) compared to 32 healthy participants (C). Saliva and serum analysis included creatinine (Cr), urea (U), calcium (Ca), phosphorous (P), magnesium (Mg) as well as intraoral pH levels.Results. All patient groups presented high DCS. DCS and pH levels were higher in the D group with a positive correlation between pH and lower incisor DCS (r = 0.56, P = 0.017). The highest salivary Ca was found in the PrD group. Salivary P in the PrD group was found to be higher than in the T and C groups. The lowest salivary Mg was found in the D group while the highest salivary Ca×P product was found in the PrD group. In all patient groups, salivary U was higher than in the C group with a 2.5-fold increase in the D group. Salivary Cr resembled the U salivary concentrations.Conclusions. Alterations in salivary Ca, P, Mg, U, Cr and intraoral pH levels were observed in the patient groups. DCS correlated with renal disease severity and therefore may be a reflection of other tissue calcification pathologies found in these patients.

AB - Background. Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports have described abundant dental calculus formation in children suffering from chronic kidney disease (CKD). Moreover, dental calculus scores (DCS) and their correlation with renal disease severity have not been studied.Methods. DCS in 74 young CKD patients were evaluated: 25 pre-dialytic (PrD), 18 on dialysis (D) and 31 with transplants (T) compared to 32 healthy participants (C). Saliva and serum analysis included creatinine (Cr), urea (U), calcium (Ca), phosphorous (P), magnesium (Mg) as well as intraoral pH levels.Results. All patient groups presented high DCS. DCS and pH levels were higher in the D group with a positive correlation between pH and lower incisor DCS (r = 0.56, P = 0.017). The highest salivary Ca was found in the PrD group. Salivary P in the PrD group was found to be higher than in the T and C groups. The lowest salivary Mg was found in the D group while the highest salivary Ca×P product was found in the PrD group. In all patient groups, salivary U was higher than in the C group with a 2.5-fold increase in the D group. Salivary Cr resembled the U salivary concentrations.Conclusions. Alterations in salivary Ca, P, Mg, U, Cr and intraoral pH levels were observed in the patient groups. DCS correlated with renal disease severity and therefore may be a reflection of other tissue calcification pathologies found in these patients.

KW - Ca × P product

KW - Chronic kidney disease

KW - Dental calculus

KW - Saliva

KW - Vascular calcifications

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JF - Nephrology Dialysis Transplantation

IS - 8

ER -

The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease

Abstract

Bibliographical note

Keywords

UN SDGs

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