The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation

M. Abraham, K. Beider, H. Wald, I. D. Weiss, D. Zipori, E. Galun, A. Nagler, O. Eizenberg, A. Peled*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Cytopenia represents a significant complication after chemotherapy, irradiation before bone marrow (BM) transplantation or as a therapy for cancer. The mechanisms that determine the pace of BM recovery are not fully understood. During the recovery phase after chemotherapy or irradiation, the signals for retention of white blood cells within the BM increase significantly. This leads to a delay in the release of WBC, which can be overcome by targeting the CXCR4 axis with the antagonist 4F-benzoyl-TN14003 (T140). The delay in the release of WBC is also accompanied by suppression in the production of progenitor cells and mature cells by the BM stroma. Administration of T140 to mice transplanted with BM cells stimulates the production of all types of progenitors and mature cells, and increases the exit of mature cells to the periphery. Moreover, addition of T140, but not AMD3100, to BM stromal cultures stimulates the production of mature cells and progenitors from all lineages. The unique ability of the CXCR4 antagonist, T140 to stimulate the production and exit of WBC cells may be used as a novel therapeutic approach to overcome cytopenia associated with treatments for cancer and BM transplantation.

Original languageAmerican English
Pages (from-to)1378-1388
Number of pages11
Issue number8
StatePublished - 2009
Externally publishedYes

Bibliographical note

Funding Information:
This work is supported by a grant from the Lady Davis Fellowship Trust and in part by a grant from Biokine Therapeutics Ltd. We thank Mery Clausen the Gene Therapy Institute, Hadassah University Hospital, Jerusalem, Israel for technical assistance.


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