The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and-resistant P388 leukemia cells

Avner Ramu*, Boris Yagen, Nili Ramu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The cytotoxicity of T-2 toxin and related trichothecenes was studied in Adriamycin-sensitive and-resistant P388 leukemia cells in vitro. The structure-activity relationship indicated that a free hydroxyl in the C-3 position contributed to the activity. Free hydroxyls at the 4, 8, and 15 positions interfered with the activity, and their estrification resulted in improved cytotoxicity. The cytotoxic activity of these trichothecenes did not seem to be related to their degree of lipophilicity. Adriamycin-resistant P388 cells were cross-resistant to the trichothecenes, and this resistance could be circumvented by verapamil.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalCancer Chemotherapy and Pharmacology
Volume24
Issue number4
DOIs
StatePublished - Oct 1989

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