The development of the chromaffin cell lineage from the neural crest

Katrin Huber, Chaya Kalcheim, Klaus Unsicker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


Chromaffin cells are neuroendocrine cells, which are highly specialized for the synthesis and release of multiple hormones. Like sympathetic neurons, which are essential, inter alia, for neural control of vascular tone, they are derivatives of the neural crest, a transient structure at the dorsal surface of the embryonic neural tube. Chromaffin cells and sympathetic neurons have many features in common, but are also distinct in several respects. This review provides a summary of similarities and differences regarding the development of chromaffin cells and sympathetic neurons, viewed from molecular and morphological perspectives. Two major, still not finally settled issues, are whether (1) the two related cell types arise from one common or two separate cell lineages of delaminating neural crest cells, (2) in the former case when does lineage segregation occur, and what are the molecules underlying their phenotypic diversification.

Original languageAmerican English
Pages (from-to)10-16
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1
StatePublished - 17 Nov 2009

Bibliographical note

Funding Information:
Work from our laboratories described in this article was supported by Deutsche Forschungsgemeinschaft (SFB488/A5,A6; SFB592/A23).


  • Adrenal gland
  • Chromaffin cells
  • Dopamine-ß hydroxylase (DBH)
  • GATA2/3
  • Glucocorticoids
  • Hand2
  • Insm1
  • Neural crest
  • Phenylethanolamine N-methyltransferase (PNMT)
  • Phox2A
  • PhoxB
  • Sympathoadrenal cell lineage
  • Tyrosine-hydroxylase (TH)


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