TY - JOUR
T1 - The diagnostic and prognostic value of sIL-2R as an immune biomarker in head and neck cancers
AU - Gross, Menachem
AU - Meirovich, Amichay
AU - Rachmut, Jakob
AU - Kalichman, Ina
AU - Peretz, Tamar
AU - Eliashar, Ron
AU - Barak, Vivian
PY - 2016/8
Y1 - 2016/8
N2 - Background/Aim: Head and neck cancer (HNC) patients are usually diagnosed with advanced disease and multimodality therapies are required, as well as prognostic biomarkers to predict their response and assess survival. In this study, we aimed to evaluate the ability and clinical significance of the immune biomarker sIL-2R in HNC patients, to assess therapy response and prognosis. Materials and Methods: We evaluated 328 blood samples from 145 head and neck cancer patients (HNC) from several subgroups: 84 larynx carcinomas pre-and 39 post-therapy, 46 oral cavity carcinomas pre-and 29 post-therapy, 12 nasopharynx carcinomas, 16 parotid and other salivary gland carcinoma patients. The control group included 45 healthy subjects. Serum sIL-2R levels were evaluated by ELISA assays and correlated to disease stage, lymph nodes, response to therapy, survival and cancer differentiation. Results: Significantly higher sIL-2R levels were recorded in all HNC patients, as opposed to controls, in advanced versus earlystage disease that decreased following therapy. sIL-2R distinguished best, in comparison to other tumor markers, between HNC patients and controls. Survival was strongly associated to lower sIL-2R levels in patients entering the study. Conclusion: sIL-2R is a sensitive immune marker for HNC patients. Its levels correlate to disease stage, assess response to therapy and are predictive of recurrence or better survival. We suggest, therefore, using sIL-2R as a reliable prognostic marker in HNC patients as a single marker, or in a combined panel of biomarkers.
AB - Background/Aim: Head and neck cancer (HNC) patients are usually diagnosed with advanced disease and multimodality therapies are required, as well as prognostic biomarkers to predict their response and assess survival. In this study, we aimed to evaluate the ability and clinical significance of the immune biomarker sIL-2R in HNC patients, to assess therapy response and prognosis. Materials and Methods: We evaluated 328 blood samples from 145 head and neck cancer patients (HNC) from several subgroups: 84 larynx carcinomas pre-and 39 post-therapy, 46 oral cavity carcinomas pre-and 29 post-therapy, 12 nasopharynx carcinomas, 16 parotid and other salivary gland carcinoma patients. The control group included 45 healthy subjects. Serum sIL-2R levels were evaluated by ELISA assays and correlated to disease stage, lymph nodes, response to therapy, survival and cancer differentiation. Results: Significantly higher sIL-2R levels were recorded in all HNC patients, as opposed to controls, in advanced versus earlystage disease that decreased following therapy. sIL-2R distinguished best, in comparison to other tumor markers, between HNC patients and controls. Survival was strongly associated to lower sIL-2R levels in patients entering the study. Conclusion: sIL-2R is a sensitive immune marker for HNC patients. Its levels correlate to disease stage, assess response to therapy and are predictive of recurrence or better survival. We suggest, therefore, using sIL-2R as a reliable prognostic marker in HNC patients as a single marker, or in a combined panel of biomarkers.
KW - Clinical utility
KW - Head and neck cancer
KW - SIL-2R
KW - Tumor markers
UR - http://www.scopus.com/inward/record.url?scp=84991777020&partnerID=8YFLogxK
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C2 - 27466555
AN - SCOPUS:84991777020
SN - 0250-7005
VL - 36
SP - 4347
EP - 4352
JO - Anticancer Research
JF - Anticancer Research
IS - 8
ER -
