TY - JOUR
T1 - The differential vulnerability of the inner ear end-organs to several external factors
AU - Perez, Ronen
AU - Cohen, David
AU - Freeman, Sharon
AU - Sohmer, Haim
AU - Sichelv, Jean Yves
PY - 2003
Y1 - 2003
N2 - In a number of recently conducted animal studies, the effect of various external factors such as ototoxic substances, different types of noise and systemic disease on the different end-organs of the inner ear has been investigated. These studies are distinguished by the use of short latency vestibular evoked potentials (VsEPs) (to both linear and angular acceleration), an objective method for directly assessing the function of the different vestibular end-organs. In addition, the well known auditory brainstem response (ABR) was used to assess cochlear function. The studies are reviewed and it appears that the general pattern of effect is as follows: ABR (cochlea) is the most sensitive to the various external factors; angular VsEPs (semicircular canals) the least sensitive; linear VsEPs (otolith organs) intermediate between them.
AB - In a number of recently conducted animal studies, the effect of various external factors such as ototoxic substances, different types of noise and systemic disease on the different end-organs of the inner ear has been investigated. These studies are distinguished by the use of short latency vestibular evoked potentials (VsEPs) (to both linear and angular acceleration), an objective method for directly assessing the function of the different vestibular end-organs. In addition, the well known auditory brainstem response (ABR) was used to assess cochlear function. The studies are reviewed and it appears that the general pattern of effect is as follows: ABR (cochlea) is the most sensitive to the various external factors; angular VsEPs (semicircular canals) the least sensitive; linear VsEPs (otolith organs) intermediate between them.
KW - ABR
KW - noise
KW - ototoxicity
KW - vestibular end-organs
KW - vestibular evoked potentials (VsEPs)
UR - http://www.scopus.com/inward/record.url?scp=0141998000&partnerID=8YFLogxK
U2 - 10.1515/JBCPP.2003.14.2.85
DO - 10.1515/JBCPP.2003.14.2.85
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C2 - 14558725
AN - SCOPUS:0141998000
SN - 0792-6855
VL - 14
SP - 85
EP - 94
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 2
ER -