TY - JOUR
T1 - The dissolution mechanism in a system undergoing complexation
T2 - salicylamide in caffeine solution
AU - DONBROW, M.
AU - TOUITOU, ELKA
PY - 1977/9
Y1 - 1977/9
N2 - The dissolution rate of compressed salicylamide discs has been measured in water and in caffeine solutions of increasing concentration at 15, 25, 37 and 45° in an apparatus rotating at 48 rev min−1 or more. Dissolution rate profiles showed breaks indicative of a shift in the mechanism of dissolution from interfacial towards transport control. The shifts occurred at higher caffeine concentrations on increasing the agitation rate or temperature. The dependencies of dissolution rates on agitation rates typified the intermediate type of dissolution and Arrhenius plots indicated that interfacial and transport processes participated in salicylamide dissolution. 1977 Royal Pharmaceutical Society of Great Britain
AB - The dissolution rate of compressed salicylamide discs has been measured in water and in caffeine solutions of increasing concentration at 15, 25, 37 and 45° in an apparatus rotating at 48 rev min−1 or more. Dissolution rate profiles showed breaks indicative of a shift in the mechanism of dissolution from interfacial towards transport control. The shifts occurred at higher caffeine concentrations on increasing the agitation rate or temperature. The dependencies of dissolution rates on agitation rates typified the intermediate type of dissolution and Arrhenius plots indicated that interfacial and transport processes participated in salicylamide dissolution. 1977 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0017689922&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1977.tb11388.x
DO - 10.1111/j.2042-7158.1977.tb11388.x
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C2 - 21254
AN - SCOPUS:0017689922
SN - 0022-3573
VL - 29
SP - 524
EP - 528
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 1
ER -