Abstract
Streptozotocin diabetes in rats produces changes in platelet aggregation. As contractile proteins and glycoproteins are associated with this process, their quantity and distribution was studied in this model on unfractionated platelets and on platelet fractions. K+ (EDTA) activated myosin ATPase activity was significantly higher in the KCl extract of diabetic rat platelets. No significant differences were observed in the amount of myosin, actin, actin-binding protein and glycoproteins in unfractionated platelets and platelet fractions. The contractile protein content of normal rat platelets were compared to those of healthy humans and differences were observed in the amount of these proteins and in the specific activity of myosin ATPase.
Original language | English |
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Pages (from-to) | 621-629 |
Number of pages | 9 |
Journal | Thrombosis Research |
Volume | 14 |
Issue number | 4-5 |
DOIs | |
State | Published - 1979 |