The distribution of platelet contractile proteins in normal and streptozotocin diabetic rats

A. Muhlrad*, A. Eldor, H. Bar-On, I. Kahane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Streptozotocin diabetes in rats produces changes in platelet aggregation. As contractile proteins and glycoproteins are associated with this process, their quantity and distribution was studied in this model on unfractionated platelets and on platelet fractions. K+ (EDTA) activated myosin ATPase activity was significantly higher in the KCl extract of diabetic rat platelets. No significant differences were observed in the amount of myosin, actin, actin-binding protein and glycoproteins in unfractionated platelets and platelet fractions. The contractile protein content of normal rat platelets were compared to those of healthy humans and differences were observed in the amount of these proteins and in the specific activity of myosin ATPase.

Original languageEnglish
Pages (from-to)621-629
Number of pages9
JournalThrombosis Research
Volume14
Issue number4-5
DOIs
StatePublished - 1979

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