TY - JOUR
T1 - The dual role of macrophages in the sporozoite-induced malaria infection. A hypothesis
AU - Verhave, J. P.
AU - Meuwissen, J. H.E.Th
AU - Golenser, J.
PY - 1980
Y1 - 1980
N2 - Macrophages were thought to act as a barrier to sporozoite entry in liver cells. Evidence is presented here for a possible dual role of macrophages under different sets of conditions. Before activation macrophages might act as transporting agents of sporozoites to the parenchymal cells of the liver. Activated macrophages however might take the opposite role of preventing parasite entry. Various possible mechanisms involved are reviewed.
AB - Macrophages were thought to act as a barrier to sporozoite entry in liver cells. Evidence is presented here for a possible dual role of macrophages under different sets of conditions. Before activation macrophages might act as transporting agents of sporozoites to the parenchymal cells of the liver. Activated macrophages however might take the opposite role of preventing parasite entry. Various possible mechanisms involved are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=0018930562&partnerID=8YFLogxK
U2 - 10.1016/0047-0740(80)90033-9
DO - 10.1016/0047-0740(80)90033-9
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C2 - 6156920
AN - SCOPUS:0018930562
SN - 0047-0740
VL - 7
SP - 149
EP - 156
JO - International Journal of Nuclear Medicine and Biology
JF - International Journal of Nuclear Medicine and Biology
IS - 2
ER -
