The dual role of macrophages in the sporozoite-induced malaria infection. A hypothesis

J. P. Verhave; J. H.E.Th Meuwissen; J. Golenser

doi:10.1016/0047-0740(80)90033-9

The dual role of macrophages in the sporozoite-induced malaria infection. A hypothesis

J. P. Verhave^*
, J. H.E.Th Meuwissen
, J. Golenser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Macrophages were thought to act as a barrier to sporozoite entry in liver cells. Evidence is presented here for a possible dual role of macrophages under different sets of conditions. Before activation macrophages might act as transporting agents of sporozoites to the parenchymal cells of the liver. Activated macrophages however might take the opposite role of preventing parasite entry. Various possible mechanisms involved are reviewed.

Original language	English
Pages (from-to)	149-156
Number of pages	8
Journal	International Journal of Nuclear Medicine and Biology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0047-0740(80)90033-9
State	Published - 1980
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/0047-0740(80)90033-9

Cite this

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abstract = "Macrophages were thought to act as a barrier to sporozoite entry in liver cells. Evidence is presented here for a possible dual role of macrophages under different sets of conditions. Before activation macrophages might act as transporting agents of sporozoites to the parenchymal cells of the liver. Activated macrophages however might take the opposite role of preventing parasite entry. Various possible mechanisms involved are reviewed.",

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AB - Macrophages were thought to act as a barrier to sporozoite entry in liver cells. Evidence is presented here for a possible dual role of macrophages under different sets of conditions. Before activation macrophages might act as transporting agents of sporozoites to the parenchymal cells of the liver. Activated macrophages however might take the opposite role of preventing parasite entry. Various possible mechanisms involved are reviewed.

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The dual role of macrophages in the sporozoite-induced malaria infection. A hypothesis

Abstract

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