TY - JOUR
T1 - The Effect of 0.12% Unoprostone Isopropyl (Rescula) on Intraocular Pressure in Normotensive Dogs
AU - Ofri, Ron
AU - Raz, Dorit
AU - Kass, Phillip H.
AU - Lambrou, George N.
AU - Percicot, Christine L.
PY - 2000/12
Y1 - 2000/12
N2 - Rescula (0.12% unoprostone isopropyl) is the first docosanoid compound approved for treatment of glaucoma in humans. It is commercially available in Japan, and is undergoing clinical testing elsewhere. The aim of this study was to evaluate the effect of Rescula on intraocular pressure (IOP) in normotensive dogs. After establishing a baseline diurnal IOP curve, six dogs were unilaterally treated with Rescula while the contralateral eye was treated with a placebo. Applanation tonometry was performed in both eyes, and pupil size was evaluated, 30 min after treatment, and at 1-hr intervals for the next 9 hr. Rescula caused a significant (p=0.014) and long-lasting decrease in IOP, from 20.49 ± 2.02 mm Hg in control eyes to 15.49 ± 0.69 mm Hg in treated eyes. These results suggest that Rescula is potentially efficacious in treatment of canine glaucoma.
AB - Rescula (0.12% unoprostone isopropyl) is the first docosanoid compound approved for treatment of glaucoma in humans. It is commercially available in Japan, and is undergoing clinical testing elsewhere. The aim of this study was to evaluate the effect of Rescula on intraocular pressure (IOP) in normotensive dogs. After establishing a baseline diurnal IOP curve, six dogs were unilaterally treated with Rescula while the contralateral eye was treated with a placebo. Applanation tonometry was performed in both eyes, and pupil size was evaluated, 30 min after treatment, and at 1-hr intervals for the next 9 hr. Rescula caused a significant (p=0.014) and long-lasting decrease in IOP, from 20.49 ± 2.02 mm Hg in control eyes to 15.49 ± 0.69 mm Hg in treated eyes. These results suggest that Rescula is potentially efficacious in treatment of canine glaucoma.
KW - Canine
KW - Glaucoma
KW - Unoprostone isopropyl
UR - http://www.scopus.com/inward/record.url?scp=0034573784&partnerID=8YFLogxK
U2 - 10.1292/jvms.62.1313
DO - 10.1292/jvms.62.1313
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C2 - 11193349
AN - SCOPUS:0034573784
SN - 0916-7250
VL - 62
SP - 1313
EP - 1315
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
IS - 12
ER -