TY - JOUR
T1 - The effect of a long-acting local anaesthetic agent (Marcaine®) on the masticatory muscle in rats
AU - Tal, Michael
PY - 1982
Y1 - 1982
N2 - Marcaine®, a long-acting local anaesthetic was administered subcutaneously over the rat's superficial masseter muscle. Rapid muscle fibre destruction with infiltration of mononuclear and polymorphonuclear leukocytes and degeneration of muscle fibers are the notable morphological changes following treatment with Marcaine®. However, this degeneration was rapidly replaced by a regeneration process. Sequential injections of Marcaine produced even more serious muscle damage. However, successive injections of the drug did not prevent the regeneration process.
AB - Marcaine®, a long-acting local anaesthetic was administered subcutaneously over the rat's superficial masseter muscle. Rapid muscle fibre destruction with infiltration of mononuclear and polymorphonuclear leukocytes and degeneration of muscle fibers are the notable morphological changes following treatment with Marcaine®. However, this degeneration was rapidly replaced by a regeneration process. Sequential injections of Marcaine produced even more serious muscle damage. However, successive injections of the drug did not prevent the regeneration process.
KW - anaesthesia, local
KW - degeneration
KW - experimental
KW - muscles, masticatory
KW - rat
UR - http://www.scopus.com/inward/record.url?scp=0019994885&partnerID=8YFLogxK
U2 - 10.1016/S0300-9785(82)80017-3
DO - 10.1016/S0300-9785(82)80017-3
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C2 - 6809668
AN - SCOPUS:0019994885
SN - 0300-9785
VL - 11
SP - 101
EP - 105
JO - International Journal of Oral Surgery
JF - International Journal of Oral Surgery
IS - 2
ER -