The effect of a long-acting local anaesthetic agent (Marcaine®) on the masticatory muscle in rats

Marcaine®, a long-acting local anaesthetic was administered subcutaneously over the rat's superficial masseter muscle. Rapid muscle fibre destruction with infiltration of mononuclear and polymorphonuclear leukocytes and degeneration of muscle fibers are the notable morphological changes following treatment with Marcaine®. However, this degeneration was rapidly replaced by a regeneration process. Sequential injections of Marcaine produced even more serious muscle damage. However, successive injections of the drug did not prevent the regeneration process.