Abstract
Sodium fluxes across the distal colon of the rabbit were studied in vitro, using 22NaCl. Sodium flux from mucosa to serosa (JNaMS) exceeded the flux from serosa to mucosa (JNaSM) resulting in net sodium movement (JNanet) from mucosa to serosa. Addition of an alpha adrenergic agonist (phenylephrine) increased JNanet by augmentation of JNaMS. An alpha-adrenergic antagonist (phentolamine) abolished the effect of phenylephrine. Sodium fluxes and the stimulation of JNaMS by phenylephrine were unaffected when calcium was omitted from the medium. Beta adrenergic agonist (isoproterenol) or theophylline did not affect JNanet, but caused a simultaneous increase of both JNaSM and JNaMS. The role innervation of the colon in the regulation of sodium transport in vivo is discussed.
Original language | English |
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Pages (from-to) | 1271-1273 |
Number of pages | 3 |
Journal | Biochemical Pharmacology |
Volume | 29 |
Issue number | 9 |
DOIs | |
State | Published - 1 May 1980 |