TY - JOUR
T1 - The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage
T2 - an electron microscopy study
AU - Kitov, Svetlana
AU - Ben-Shoshan, Raphael
AU - Ringel, Israel
AU - Gibson, Dan
AU - Katzhendler, Jehoshua
PY - 1988
Y1 - 1988
N2 - The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH2)3NH2)2PtCl2, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.
AB - The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH2)3NH2)2PtCl2, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.
KW - DNA
KW - electron microscopy
KW - platinum complexes
UR - http://www.scopus.com/inward/record.url?scp=0023772990&partnerID=8YFLogxK
U2 - 10.1016/0223-5234(88)90213-9
DO - 10.1016/0223-5234(88)90213-9
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AN - SCOPUS:0023772990
SN - 0223-5234
VL - 23
SP - 381
EP - 383
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 4
ER -