The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study

Svetlana Kitov; Raphael Ben-Shoshan; Israel Ringel; Dan Gibson; Jehoshua Katzhendler

doi:10.1016/0223-5234(88)90213-9

The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study

Svetlana Kitov^*
, Raphael Ben-Shoshan
, Israel Ringel
, Dan Gibson
, Jehoshua Katzhendler

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH₂)₃NH₂)₂PtCl₂, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.

Original language	English
Pages (from-to)	381-383
Number of pages	3
Journal	European Journal of Medicinal Chemistry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/0223-5234(88)90213-9
State	Published - 1988

Keywords

DNA
electron microscopy
platinum complexes

Access to Document

10.1016/0223-5234(88)90213-9

Cite this

@article{92c18090f7a34cb4b2a8c74919063696,

title = "The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study",

abstract = "The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH2)3NH2)2PtCl2, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.",

keywords = "DNA, electron microscopy, platinum complexes",

author = "Svetlana Kitov and Raphael Ben-Shoshan and Israel Ringel and Dan Gibson and Jehoshua Katzhendler",

year = "1988",

doi = "10.1016/0223-5234(88)90213-9",

language = "אנגלית",

volume = "23",

pages = "381--383",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "4",

}

TY - JOUR

T1 - The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage

T2 - an electron microscopy study

AU - Kitov, Svetlana

AU - Ben-Shoshan, Raphael

AU - Ringel, Israel

AU - Gibson, Dan

AU - Katzhendler, Jehoshua

PY - 1988

Y1 - 1988

N2 - The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH2)3NH2)2PtCl2, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.

AB - The effects of cis-diamminedichloroplatinum(II) (cis-DDP) and a new analog (cis-DANAP) derived from aminoalkylaminoanthraquinones (RNH(CH2)3NH2)2PtCl2, R = anthraquinone on the oligonucleotide poly(dG)·poly(dC) were studied by electron microscopy. It was observed that with cis-DANAP, the extent of small fragments increased with the increase of the drug/nucleotide molar ratio (Rb). This effect was not observed with cis-DDP and with the parent aminoalkylaminoanthraquinone free base. The effect was not time dependent and could be observed only at Rb > 0.4. Explanation for this phenomenon was given on the basis of monoadduct formation between the platinum and purine/pyrimidine bases which leads to strand degradation. A salt effect on the length of poly(dG)·poly(dC) is also present.

KW - DNA

KW - electron microscopy

KW - platinum complexes

UR - https://www.scopus.com/pages/publications/0023772990

U2 - 10.1016/0223-5234(88)90213-9

DO - 10.1016/0223-5234(88)90213-9

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0023772990

SN - 0223-5234

VL - 23

SP - 381

EP - 383

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 4

ER -

The effect of cis-platin analogues derived from aminoalkylaminoanthraquinones on DNA cleavage: an electron microscopy study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this