The effect of drugs altering striatal dopamine levels on apomorphine induced stereotypy

Jeffery J. Feigenbaum*, Joseph Yanai, Rachel B. Blass, Byong Moon, Harold Klawans

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Drugs that increase or decrease striatal dopamine levels appear to affect apomorphine induced stereotypy. This finding was unexpected, as it has previously been maintained that drugs which exert any action on striatal DA terminals exclusively would affect only indirect dopaminergic agonists, as opposed to apomorphine which induces stereotypy by acting directly on postsynaptic dopamine receptors. Specifically, inhibiting intrastriatal dopamine levels inhibits this behavior. This effect is explained in terms of apomorphine having a greater intrinsic activity and agonist affinity for striatal dopamine receptors than dopamine itself. Thus, dopamine and drugs which promote its release, may diminish the central behavioral effects induced by apomorphine relative to drugs which inhibit dopamine release centrally.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume16
Issue number2
DOIs
StatePublished - Feb 1982
Externally publishedYes

Keywords

  • Amphetamine
  • Apomorphine
  • Dopamine
  • Post-synaptic striatal dopamine receptor
  • Stereotypy
  • α-Methyl-p-tyrosine
  • γ-Hydroxybutyrate

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