TY - JOUR
T1 - The effect of electrolytic lesions in the baso-medial-hypothalamus on the immune response of the chicken
AU - Karin, N.
AU - Heller, E. D.
AU - Snapir, N.
AU - Robinzon, B.
AU - Friedman, A.
PY - 1988
Y1 - 1988
N2 - Electrolytic lesions of the baso-medial-hypothalamus (BMH) cause numerous dysfunctions of the endocrine system, many of which have been implicated in regulating immune responses. The objective of this report was to evaluate the direct effects of electrolytic lesions in the BMH on the immune response of the chicken. Our results indicate that temporary immune response impairment, as evaluated by both T and B lymphocyte related responses, occurred only in birds that expressed both brain damage and endocrine dysfunction, whereas birds expressing brain damage alone had normal immune responses. The possible regulation of immune responses by the BMH via the endocrine system is discussed.
AB - Electrolytic lesions of the baso-medial-hypothalamus (BMH) cause numerous dysfunctions of the endocrine system, many of which have been implicated in regulating immune responses. The objective of this report was to evaluate the direct effects of electrolytic lesions in the BMH on the immune response of the chicken. Our results indicate that temporary immune response impairment, as evaluated by both T and B lymphocyte related responses, occurred only in birds that expressed both brain damage and endocrine dysfunction, whereas birds expressing brain damage alone had normal immune responses. The possible regulation of immune responses by the BMH via the endocrine system is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0024240112&partnerID=8YFLogxK
U2 - 10.1016/0145-305X(88)90057-2
DO - 10.1016/0145-305X(88)90057-2
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C2 - 3145223
AN - SCOPUS:0024240112
SN - 0145-305X
VL - 12
SP - 833
EP - 842
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 4
ER -