The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity

H. Ginsburg*, R. A. Demel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Ferriprotoporphyrin IX intercalates into phospholipid membranes, as evidenced from its effect on the surface pressure of monolayers composed of different phospholipids. Ferriprotoporphyrin intercalation is enhanced by membrane hydrophobicity and decreased by negative surface potential. Chloroquine enhances the effect of ferriprotoporphyrin in relatively hydrophobic membranes but reduces it in monolayers composed of highly unsaturated phospholipids. These results are consistent with the differential effect of chloroquine on ferriprotoporphyrin-induced lysis of erythrocytes and of malarial parasites, thus supporting the membrane-lesion hypothesis of antimalarial action.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume732
Issue number1
DOIs
StatePublished - 13 Jul 1983

Keywords

  • Chloroquine
  • Ferriprotoporphyrin
  • Intercalation
  • Malaria
  • Phospholipid monolayers

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