The effect of free radicals induced by paraquat and copper on the in vitro development of plasmodium falciparum

Esther Marva; Mordechai Chevion; Jacob Golenser

doi:10.3109/10715769109145778

The effect of free radicals induced by paraquat and copper on the in vitro development of plasmodium falciparum

Esther Marva^*, Mordechai Chevion, Jacob Golenser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The role of transition metals in paraquat toxicity was studied in cultures of Plasmodium falciparum. We showed that addition of copper led to an enhancement of the plasmodium killing, whereas addition of chelating agents. such as desferrioxamine and diethylenetriamine pentaacetic acid markedly reduced the toxic effects. Parsitized G6PD deficient erythrocytes were more sensitive than parasitized normal eryth-rocytes to copper and to the combination of copper and paraquat.

Original language	English
Pages (from-to)	137-146
Number of pages	10
Journal	Free Radical Research
Volume	12
Issue number	1
DOIs	https://doi.org/10.3109/10715769109145778
State	Published - 1991

Keywords

Malaria
Oxidant stress
Paraquat
Transition metals

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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The effect of free radicals induced by paraquat and copper on the in vitro development of plasmodium falciparum

Abstract

Keywords

UN SDGs

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