The effect of glucagon on plasma cyclic AMP levels in young and elderly subjects

J. Stessman; R. Eliakim; R. P. Ebstein

doi:10.1007/BF02432204

The effect of glucagon on plasma cyclic AMP levels in young and elderly subjects

J. Stessman
, R. Eliakim
, R. P. Ebstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Glucagon-induced rise in plasma cyclic AMP levels was used to study glucagon-sensitive adenylate cyclase activity in aged man. No significant difference was observed in plasma cyclic AMP rise after glucagon (0.0004 mg/kg) infusion between a group of 9 older (mean age 78 years) and 9 younger individuals (mean age 31 years). A similar rise in plasma glucose levels 10-15 min after glucagon administration was observed in both the younger and older individuals. These results are discussed in relation to previous findings of reduced beta-adrenergic-stimulated adenylate cyclase activity in aged man.

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Age
Volume	7
Issue number	3
DOIs	https://doi.org/10.1007/BF02432204
State	Published - Jul 1984
Externally published	Yes

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abstract = "Glucagon-induced rise in plasma cyclic AMP levels was used to study glucagon-sensitive adenylate cyclase activity in aged man. No significant difference was observed in plasma cyclic AMP rise after glucagon (0.0004 mg/kg) infusion between a group of 9 older (mean age 78 years) and 9 younger individuals (mean age 31 years). A similar rise in plasma glucose levels 10-15 min after glucagon administration was observed in both the younger and older individuals. These results are discussed in relation to previous findings of reduced beta-adrenergic-stimulated adenylate cyclase activity in aged man.",

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AB - Glucagon-induced rise in plasma cyclic AMP levels was used to study glucagon-sensitive adenylate cyclase activity in aged man. No significant difference was observed in plasma cyclic AMP rise after glucagon (0.0004 mg/kg) infusion between a group of 9 older (mean age 78 years) and 9 younger individuals (mean age 31 years). A similar rise in plasma glucose levels 10-15 min after glucagon administration was observed in both the younger and older individuals. These results are discussed in relation to previous findings of reduced beta-adrenergic-stimulated adenylate cyclase activity in aged man.

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The effect of glucagon on plasma cyclic AMP levels in young and elderly subjects

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