The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus

A. Hoffman*, Y. Fischer, D. Gilhar, I. Raz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.

Original languageAmerican English
Pages (from-to)53-55
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume47
Issue number1
DOIs
StatePublished - Aug 1994

Keywords

  • Diabetes
  • Glibenclamide
  • NIDDM
  • absorption
  • hyperglycaemia
  • pharmacokinetics

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