The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus

A. Hoffman; Y. Fischer; D. Gilhar; I. Raz

doi:10.1007/BF00193478

The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus

A. Hoffman^*, Y. Fischer, D. Gilhar, I. Raz

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1^-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.

Original language	English
Pages (from-to)	53-55
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/BF00193478
State	Published - Aug 1994

Keywords

Diabetes
Glibenclamide
NIDDM
absorption
hyperglycaemia
pharmacokinetics

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10.1007/BF00193478

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abstract = "We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.",

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AB - We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.

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KW - Glibenclamide

KW - NIDDM

KW - absorption

KW - hyperglycaemia

KW - pharmacokinetics

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The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus

Abstract

Keywords

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