Abstract
We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.
| Original language | English |
|---|---|
| Pages (from-to) | 53-55 |
| Number of pages | 3 |
| Journal | European Journal of Clinical Pharmacology |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1994 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Diabetes
- Glibenclamide
- NIDDM
- absorption
- hyperglycaemia
- pharmacokinetics
Fingerprint
Dive into the research topics of 'The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver