The effect of immunization on the response to P. gingivalis infection in mice is adjuvant-dependent

Yael Houri-Haddad*, W. Aubrey Soskolne, Amal Halabi, Lior Shapira

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Aim: Studies on vaccines against the periodontal pathogen Porphyromonas gingivalis have produced conflicting results, but no consideration has been given to the role of different adjuvants in these vaccines. We have previously shown that an intra-chamber challenge with heat-killed P. gingivalis was modified by immunization with different adjuvants. This study tested the hypothesis that different adjuvants in P. gingivalis vaccines would differentially modify the host response to a live P. gingivalis infection. Results: Using P. gingivalis-infected subcutaneous chambers in mice, we show that vaccination with P. gingivalis in alum attenuated the pro-inflammatory cytokine levels at the site of infection, while the vaccine containing incomplete Freund's adjuvant did the opposite. Although both vaccines induced a similar humoral IgG response, P. gingivalis-induced abscesses were significantly smaller in the alum-adjuvant group. Conclusions: The results suggest that the immune response and the resultant protection to a P. gingivalis infection, in P. gingivalis-vaccinated mice, are adjuvant-dependent.

Original languageAmerican English
Pages (from-to)933-937
Number of pages5
JournalJournal of Clinical Periodontology
Volume32
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Keywords

  • Cytokines
  • Inflammation
  • Porphyromonas gingivalis
  • Porphyromonas gingivalis/humoral response
  • Th1/Th2
  • Vaccine/adjuvant

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