The effect of isatin β thiosemicarbazone (IBT) related compounds on IBT resistant and on IBT dependent mutants of vaccinia virus

E. Katz, E. Margalith, B. Winer

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

IBT related compounds were examined for their ability to inhibit wild type and IBT resistant mutants of vaccinia virus and for their capability to support the growth of an IBT dependent mutant. Among thirteen compounds tested, six did not affect any one of the three virus strains and five behaved similarly to IBT, but two inhibited the growth of all three viruses and therefore differed from IBT. It was found that the last two compounds also differed from IBT in that they interfered with synthesis of the virus DNA. This difference is surprising in view of a substantial similarity in chemical structure.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalJournal of General Virology
Volume25
Issue number2
DOIs
StatePublished - 1974

Fingerprint

Dive into the research topics of 'The effect of isatin β thiosemicarbazone (IBT) related compounds on IBT resistant and on IBT dependent mutants of vaccinia virus'. Together they form a unique fingerprint.

Cite this