TY - JOUR
T1 - The effect of isatin β thiosemicarbazone (IBT) related compounds on IBT resistant and on IBT dependent mutants of vaccinia virus
AU - Katz, E.
AU - Margalith, E.
AU - Winer, B.
PY - 1974
Y1 - 1974
N2 - IBT related compounds were examined for their ability to inhibit wild type and IBT resistant mutants of vaccinia virus and for their capability to support the growth of an IBT dependent mutant. Among thirteen compounds tested, six did not affect any one of the three virus strains and five behaved similarly to IBT, but two inhibited the growth of all three viruses and therefore differed from IBT. It was found that the last two compounds also differed from IBT in that they interfered with synthesis of the virus DNA. This difference is surprising in view of a substantial similarity in chemical structure.
AB - IBT related compounds were examined for their ability to inhibit wild type and IBT resistant mutants of vaccinia virus and for their capability to support the growth of an IBT dependent mutant. Among thirteen compounds tested, six did not affect any one of the three virus strains and five behaved similarly to IBT, but two inhibited the growth of all three viruses and therefore differed from IBT. It was found that the last two compounds also differed from IBT in that they interfered with synthesis of the virus DNA. This difference is surprising in view of a substantial similarity in chemical structure.
UR - http://www.scopus.com/inward/record.url?scp=0016213881&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-25-2-239
DO - 10.1099/0022-1317-25-2-239
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C2 - 4373528
AN - SCOPUS:0016213881
SN - 0022-1317
VL - 25
SP - 239
EP - 244
JO - Journal of General Virology
JF - Journal of General Virology
IS - 2
ER -