The effect of magnesium on the time course of facilitation at the crayfish neuromuscular junction

J. Dudel; H. Parnas; I. Parnas

doi:10.1016/0304-3940(81)90081-1

The effect of magnesium on the time course of facilitation at the crayfish neuromuscular junction

J. Dudel^*
, H. Parnas
, I. Parnas

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Synaptic currents (EPSCs) were recorded extracellularly from single junctions. Pairs of EPSCs were elicited at different intervals, the increase of amplitude of the second one indicating facilitation. Elevated Mg concentrations reduced the amplitude of the EPSC and prolonged facilitation. Also, if the amplitude of the EPSCs at high Mg is made the same as in the control, by raising [Ca]₀, facilitation is still prolonged. It is concluded that Mg inhibits not only the entry of Ca into the nerve terminal but also its removal.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Neuroscience Letters
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(81)90081-1
State	Published - 10 Mar 1981

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abstract = "Synaptic currents (EPSCs) were recorded extracellularly from single junctions. Pairs of EPSCs were elicited at different intervals, the increase of amplitude of the second one indicating facilitation. Elevated Mg concentrations reduced the amplitude of the EPSC and prolonged facilitation. Also, if the amplitude of the EPSCs at high Mg is made the same as in the control, by raising [Ca]0, facilitation is still prolonged. It is concluded that Mg inhibits not only the entry of Ca into the nerve terminal but also its removal.",

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The effect of magnesium on the time course of facilitation at the crayfish neuromuscular junction

Abstract

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