The effect of oil nature in o/w submicron emulsion on the oral absorption profile of physostigmine salicylate in rats

J. Kleinstern, E. Markowitz, S. Benita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Physostigmine, advocated in the treatment of Alzheimer's disease, was incorporated in various o/w emulsions in an attempt to achieve a slow release preparation with improved bioavailability. Despite the use of different oil types, no significant improvement was attained in the awake rat model. Furthermore, increasing the viscosity by adding sodium alginate and increasing the phospholipid concentration in the emulsion failed to retain physostigmine under perfect sink conditions as confirmed by the in vitro and in vivo results. Further studies are being carried out to improve the current formulation.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalS.T.P. Pharma Sciences
Volume3
Issue number2
StatePublished - 1993

Keywords

  • Alzheimer's disease
  • cholinesterase inhibition
  • in vitro release
  • physostigmine salicylate
  • submicron emulsions

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