The effect of oxotremorine on blood pressure and plasma catecholamines in conscious and anesthetized rats

Marta Weinstock; Anthony P. Zavadil; Chuang C. Chiueh; Irwin J. Kopin

doi:10.1016/0024-3205(79)90326-6

The effect of oxotremorine on blood pressure and plasma catecholamines in conscious and anesthetized rats

Marta Weinstock^*, Anthony P. Zavadil, Chuang C. Chiueh, Irwin J. Kopin

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Oxotremorine causes a pressor response in conscious rats which is associated with a large increase in circulating catecholamines. This effect is reduced by urethane and abolished by pentobarbital anesthesia. Atropine methyl nitrate antagonises the initial brady-cardia and hypotension induced by oxotremorine and reduces significantly the rise in plasma norepinephrine but not that of epinephrine. Oxotremorine appears to activate the sympathetic nervous system by at least two mechanisms: reflexly through baroreceptors, and directly by stimulation of muscarinic receptors in the central nervous system.

Original language	English
Pages (from-to)	301-309
Number of pages	9
Journal	Life Sciences
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(79)90326-6
State	Published - 22 Jan 1979

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abstract = "Oxotremorine causes a pressor response in conscious rats which is associated with a large increase in circulating catecholamines. This effect is reduced by urethane and abolished by pentobarbital anesthesia. Atropine methyl nitrate antagonises the initial brady-cardia and hypotension induced by oxotremorine and reduces significantly the rise in plasma norepinephrine but not that of epinephrine. Oxotremorine appears to activate the sympathetic nervous system by at least two mechanisms: reflexly through baroreceptors, and directly by stimulation of muscarinic receptors in the central nervous system.",

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AU - Kopin, Irwin J.

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AB - Oxotremorine causes a pressor response in conscious rats which is associated with a large increase in circulating catecholamines. This effect is reduced by urethane and abolished by pentobarbital anesthesia. Atropine methyl nitrate antagonises the initial brady-cardia and hypotension induced by oxotremorine and reduces significantly the rise in plasma norepinephrine but not that of epinephrine. Oxotremorine appears to activate the sympathetic nervous system by at least two mechanisms: reflexly through baroreceptors, and directly by stimulation of muscarinic receptors in the central nervous system.

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The effect of oxotremorine on blood pressure and plasma catecholamines in conscious and anesthetized rats

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