The effect of parabens in a mouthwash and incorporated into a sustained release varnish on salivary bacteria

D. Steinberg*, Z. Hirschfeld, I. Tayeb, S. Ben-Yosef, A. David, M. Friedman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objectives: The purpose of this study was to evaluate the antimicrobial efficacy of parabens, in a mouthwash and in a slow release device, against cariogenic bacteria in the oral cavity. Methods: Parabens were formulated in a mouthwash or in a topical slow release varnish preparation. In two separate studies, volunteers were asked to use the mouthwash or the slow release varnish applied in a personal night guard device. The levels of mutans streptococci (MS), Lactobacilli (LB) and total cultivated bacteria were measured before and after using the mouthwash or the slow release varnish. Results: The mouthwash containing parabens had a minor and a short-term effect on MS and LB counts in human saliva. The use of slow release varnish containing parabens, applied in a night guard, had a prolonged antibacterial effect on both MS and LB counts. Conclusions: Parabens in a mouthwash had little effect on oral bacteria counts; however, paraben in the slow release device had a significant and an extended effect in reducing oral bacteria. Although substantial reductions in oral bacterial counts were recorded after the use of parabens in a slow release device, this effect could probably be enhanced by an improved pharmaceutical formulation.

Original languageAmerican English
Pages (from-to)101-106
Number of pages6
JournalJournal of Dentistry
Volume27
Issue number2
DOIs
StatePublished - Feb 1999
Externally publishedYes

Keywords

  • Lactobacilli
  • Mouthwash
  • Mutans streptococci
  • Parabens
  • Slow release varnish

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