The effect of piperine on oral absorption of cannabidiol following acute vs. chronic administration

Dvora Izgelov, Abraham J. Domb, Amnon Hoffman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Piperine is an alkaloid naturally found in black pepper with a myriad of pharmacological attributes. Piperine's most far reaching indication is drug absorption enhancment, with supportive data regarding its ability to inhibit first pass effect mechanisms. However, alongside these findings, the role of piperine as an absorption enhancer is undermined with publications stating an apparent effect of a metabolic inducer. The aim of this work is to investigate the effect of repeated administration of piperine in a lipid-based formulation, on oral absorption of cannabidiol (CBD), compared to acute piperine dosing. The effect of piperine on CBD absorption was determined pre-clinically in the freely moving rat model. Results of this work demonstrated that there was no significant difference in piperine's effect, when given chronically or in a single dose regimen. Both groups resulted in approximate 2.5-fold increase in oral bioavailability of CBD compared to control group without piperine.

Original languageAmerican English
Article number105313
JournalEuropean Journal of Pharmaceutical Sciences
StatePublished - 30 May 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.


  • Cannabidiol
  • First pass effect
  • Oral absorption
  • Piperine


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