The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model

A. Yaffe*, G. Golomb, E. Breuer, I. Binderman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Background: Periodontal surgery stimulates osteoclast activity, leading to varying amounts of alveolar crest loss. We have established that topical application of 20 mg/ml of alendronate placed at the surgical mucoperiosteal site produced a striking reduction of alveolar bone loss in the rat model. The aim of this investigation was to examine the antiresorptive efficacy of 3 novel bisacylphosphonates topically delivered at the surgical site, in comparison to alendronate and etidronate which are in clinical use. Methods: Mucoperiosteal flap (MF) surgery was performed on the buccal and lingual aspects next to molars on both sides of the rat mandible. A gelatin sponge soaked in the bisphosphonate solution prepared by dissolving 20 mg of the bisphosphonate (alendronate, etidronate, VS-5, VS-6, ISA-13, SuBP) in I ml of saline was applied to exposed bone on the right side of the mandible (experimental, MF + BPs) and the left side was treated with saline only (control, MF + S). Sections were evaluated for bone loss using microradiography pattern and amount. Results: The 3 novel bisacylphosphonates, VS-5 VS-6, and ISA-13 were more effective than etidronate, and less effective than alendronate. The most effective among this group was ISA-13 followed by VS-5 and VS-6. Conclusion: We conclude that ISA-13-like alendronate is effective in reducing alveolar bone loss when delivered at surgical sites. Since ISA-13 is well absorbed through mucose tissues, we suggest that ISA-13 efficacy on reducing bone loss should be tested by its application on the mucosal tissue.

Original languageEnglish
Pages (from-to)1607-1612
Number of pages6
JournalJournal of Periodontology
Volume71
Issue number10
DOIs
StatePublished - Oct 2000

Keywords

  • Alendronate/therapeutic use
  • Alveolar bone loss/prevention and control
  • Animal studies
  • Bisphosphates/therapeutic use
  • Comparison studies
  • Etidronate/therapeutic use

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