The effects of fluid composition and shear conditions on bacterial adhesion to an antifouling peptide-coated surface

Patrícia Alves, Sivan Nir, Meital Reches, Filipe Mergulhão*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Biofilms can damage implants and are difficult to treat. Here, we assessed the performance of a tripeptide that self-assembles into an antifouling coating over a broad range of shear conditions that are relevant to biomedical applications. Adhesion assays were performed using a parallel plate flow chamber. The results show that the coating can reduce Escherichia coli adhesion up to 70% when compared with glass. At a shear rate of 15/s, typical for urinary catheters, the coating reduced the adhesion by more than 50%. These findings suggest critical features that should be considered when developing surfaces for biomedical purposes.

Original languageAmerican English
Pages (from-to)938-946
Number of pages9
JournalMRS Communications
Volume8
Issue number3
DOIs
StatePublished - 1 Sep 2018

Bibliographical note

Publisher Copyright:
Copyright © Materials Research Society 2018.

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