TY - JOUR
T1 - The effects of isouramil on erythrocyte mechanics
T2 - implications for favism.
AU - Chevion, M.
AU - Navok, T.
AU - Pfafferott, C.
AU - Meiselman, H. J.
AU - Hochstein, P.
PY - 1984/6
Y1 - 1984/6
N2 - Isouramil is one of the two aglycones derived from broad beans (Vicia faba) with the capacity to autoxidize and generate hydrogen peroxide. During its incubation with erythrocytes in vitro, it causes a marked decrease in cellular deformability at low shear forces, as measured by cone plate viscometry. At the same time the membrane shear modulus of elasticity, as determined by the dimensions of pressure induced pseudopods (PIPs), is increased. These experiments suggest that alterations in the mechanical properties of erythrocyte membranes may be the basis for changes in cellular deformability and hence, erythrocyte sequestration in G-6PD deficient cells exposed to peroxide-generating agents, such as isouramil.
AB - Isouramil is one of the two aglycones derived from broad beans (Vicia faba) with the capacity to autoxidize and generate hydrogen peroxide. During its incubation with erythrocytes in vitro, it causes a marked decrease in cellular deformability at low shear forces, as measured by cone plate viscometry. At the same time the membrane shear modulus of elasticity, as determined by the dimensions of pressure induced pseudopods (PIPs), is increased. These experiments suggest that alterations in the mechanical properties of erythrocyte membranes may be the basis for changes in cellular deformability and hence, erythrocyte sequestration in G-6PD deficient cells exposed to peroxide-generating agents, such as isouramil.
UR - http://www.scopus.com/inward/record.url?scp=0021437183&partnerID=8YFLogxK
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C2 - 6546147
AN - SCOPUS:0021437183
SN - 0740-9451
VL - 1
SP - 295
EP - 306
JO - Microcirculation, endothelium, and lymphatics
JF - Microcirculation, endothelium, and lymphatics
IS - 3
ER -