The effects of NMDA receptor antagonists on acute morphine antinociception in mice

E. Kozela*, P. Popik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Antagonists of the N-methyl-D-aspartate (NMDA) receptor complex inhibit the development of tolerance to anti-nociceptive effects of morphine and upon acute administration, influence morphine antinociceptive activity. The analysis of numerous studies investigating acute interaction between NMDA receptor antagonists and morphine in mice indicate a variety of procedural differences and reveal that these compounds may potentiate, attenuate and produce no effect on morphine antinociception. The conditions responsible for such conflicting experimental outcome of acute interaction remain unclear. It appears that the effects of NMDA receptor antagonists on morphine tolerance are not causally related to their acute effects on morphine antinociception.

Original languageAmerican English
Pages (from-to)163-168
Number of pages6
JournalAmino Acids
Volume23
Issue number1-3
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Antinociception
  • Glutamate
  • Morphine
  • NMDA receptor antagonists
  • Opiates
  • Pain

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