The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Yehuda Shavit; Gila Fish; Gilly Wolf; Eduard Mayburd; Ylia Meerson; Raz Yirmiya; Benzion Beilin

doi:10.1213/01.ane.0000167771.98680.a7

The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Yehuda Shavit^*, Gila Fish, Gilly Wolf, Eduard Mayburd, Ylia Meerson, Raz Yirmiya, Benzion Beilin

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.

Original language	English
Pages (from-to)	1112-1116
Number of pages	5
Journal	Anesthesia and Analgesia
Volume	101
Issue number	4
DOIs	https://doi.org/10.1213/01.ane.0000167771.98680.a7
State	Published - Oct 2005

Bibliographical note

Funding Information:
Supported, in part, by the State Public Committee for the Designation of Estate Funds upon the recommendation of the Chief Scientist’s Office of the Ministry of Health, Jerusalem, Israel and by a grant from the Hebrew University Intramural Research Fund Basic Project Award (YS).

Access to Document

10.1213/01.ane.0000167771.98680.a7

Cite this

@article{7299e0196c1849af9dbb0daa833e0377,

title = "The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats",

abstract = "We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.",

author = "Yehuda Shavit and Gila Fish and Gilly Wolf and Eduard Mayburd and Ylia Meerson and Raz Yirmiya and Benzion Beilin",

note = "Funding Information: Supported, in part, by the State Public Committee for the Designation of Estate Funds upon the recommendation of the Chief Scientist{\textquoteright}s Office of the Ministry of Health, Jerusalem, Israel and by a grant from the Hebrew University Intramural Research Fund Basic Project Award (YS). ",

year = "2005",

month = oct,

doi = "10.1213/01.ane.0000167771.98680.a7",

language = "אנגלית",

volume = "101",

pages = "1112--1116",

journal = "Anesthesia and Analgesia",

issn = "0003-2999",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "4",

}

TY - JOUR

T1 - The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

AU - Shavit, Yehuda

AU - Fish, Gila

AU - Wolf, Gilly

AU - Mayburd, Eduard

AU - Meerson, Ylia

AU - Yirmiya, Raz

AU - Beilin, Benzion

N1 - Funding Information: Supported, in part, by the State Public Committee for the Designation of Estate Funds upon the recommendation of the Chief Scientist’s Office of the Ministry of Health, Jerusalem, Israel and by a grant from the Hebrew University Intramural Research Fund Basic Project Award (YS).

PY - 2005/10

Y1 - 2005/10

N2 - We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.

AB - We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.

UR - http://www.scopus.com/inward/record.url?scp=25644435580&partnerID=8YFLogxK

U2 - 10.1213/01.ane.0000167771.98680.a7

DO - 10.1213/01.ane.0000167771.98680.a7

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 16192530

AN - SCOPUS:25644435580

SN - 0003-2999

VL - 101

SP - 1112

EP - 1116

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

IS - 4

ER -

The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this