The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Yehuda Shavit; Gila Fish; Gilly Wolf; Eduard Mayburd; Ylia Meerson; Raz Yirmiya; Benzion Beilin

doi:10.1213/01.ane.0000167771.98680.a7

The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Yehuda Shavit^*
, Gila Fish
, Gilly Wolf
, Eduard Mayburd
, Ylia Meerson
, Raz Yirmiya
, Benzion Beilin

^*Corresponding author for this work

Department of Psychology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.

Original language	English
Pages (from-to)	1112-1116
Number of pages	5
Journal	Anesthesia and Analgesia
Volume	101
Issue number	4
DOIs	https://doi.org/10.1213/01.ane.0000167771.98680.a7
State	Published - Oct 2005

Bibliographical note

Funding Information:
Supported, in part, by the State Public Committee for the Designation of Estate Funds upon the recommendation of the Chief Scientist’s Office of the Ministry of Health, Jerusalem, Israel and by a grant from the Hebrew University Intramural Research Fund Basic Project Award (YS).

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title = "The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats",

abstract = "We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.",

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AU - Mayburd, Eduard

AU - Meerson, Ylia

AU - Yirmiya, Raz

AU - Beilin, Benzion

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The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Abstract

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