The emergence of proteome-wide technologies: Systematic analysis of proteins comes of age

Michal Breker, Maya Schuldiner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

During the lifetime of a cell proteins can change their localization, alter their abundance and undergo modifications, all of which cannot be assayed by tracking mRNAs alone. Methods to study proteomes directly are coming of age, thereby opening new perspectives on the role of post-translational regulation in stabilizing the cellular milieu. Proteomics has undergone a revolution, and novel technologies for the systematic analysis of proteins have emerged. These methods can expand our ability to acquire information from single proteins to proteomes, from static to dynamic measures and from the population level to the level of single cells. Such approaches promise that proteomes will soon be studied at a similar level of dynamic resolution as has been the norm for transcriptomes.

Original languageAmerican English
Pages (from-to)453-464
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume15
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

Bibliographical note

Funding Information:
Work in the authors’ laboratory is supported by a European Research Council (ERC) C Starting Grant (260395). M.S. is a European Molecular Biology Organization (EMBO) Young Investigator.

Fingerprint

Dive into the research topics of 'The emergence of proteome-wide technologies: Systematic analysis of proteins comes of age'. Together they form a unique fingerprint.

Cite this