TY - JOUR
T1 - The evaluation of x-ray-induced chromosome aberrations in cell-cultures of the chinese hamster
AU - Greenblatt, Charles L.
PY - 1961
Y1 - 1961
N2 - The sources of variation in the evaluation of x-ray-induced chromosome aberrations in cell cultures of Chinese hamster (Cricetulus griseus) are discussed. The most important of these, in determining the nature and number of the lesions, seems to be the time of observation in relation to the growth of the cells. The number of visibly damaged mitoses in the first generation after irradiation in cells in metaphase and anaphase is consistent with the number of cells incapable of proliferation. From calculations of the number of chromosome aberrations occurring in these cells and their survival-curve, a working hypothesis is proposed which seems consistent with many features of cellular death due to radiation.
AB - The sources of variation in the evaluation of x-ray-induced chromosome aberrations in cell cultures of Chinese hamster (Cricetulus griseus) are discussed. The most important of these, in determining the nature and number of the lesions, seems to be the time of observation in relation to the growth of the cells. The number of visibly damaged mitoses in the first generation after irradiation in cells in metaphase and anaphase is consistent with the number of cells incapable of proliferation. From calculations of the number of chromosome aberrations occurring in these cells and their survival-curve, a working hypothesis is proposed which seems consistent with many features of cellular death due to radiation.
UR - http://www.scopus.com/inward/record.url?scp=15144357631&partnerID=8YFLogxK
U2 - 10.1080/09553006114551111
DO - 10.1080/09553006114551111
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C2 - 13901497
AN - SCOPUS:15144357631
SN - 0955-3002
VL - 4
SP - 185
EP - 210
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 2
ER -