The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: An unexpected observation

Ichchha Madan, Roberto Romero*, Juan Pedro Kusanovic, Pooja Mittal, Tinnakorn Chaiworapongsa, Zhong Dong, Shali Mazaki-Tovi, Edi Vaisbuch, Zeynep Alpay Savasan, L. Yeo, Chong Jai Kim, Sonia S. Hassan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Objective: Idiopathic vaginal bleeding, a common complication of pregnancy, increases the risk of small-for-gestational age (SGA) neonate, preeclampsia and preterm delivery and can be the only clinical manifestation of intra-amniotic infection and/or inflammation (IAI). Placenta previa is thought to be protective against ascending intrauterine infection, yet an excess of histologic chorioamnionitis has been reported in this condition. The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor. Study design: A retrospective cohort study including 35 women with placenta previa and vaginal bleeding <37 weeks of gestation who underwent amniocentesis was undertaken. Patients with multiple gestations were excluded. Intra-amniotic infection was defined as a positive culture for microorganisms, and intra-amniotic inflammation as an elevated amniotic fluid interleukin (IL)-6 concentration. IL-6 concentrations were determined by ELISA in 28 amniotic fluid samples available. Non-parametric statistics were used for analysis.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalJournal of Perinatal Medicine
Volume38
Issue number3
DOIs
StatePublished - 1 May 2010
Externally publishedYes

Keywords

  • Chorioamnionitis
  • Cytokines
  • Deciduitis
  • Idiopathic vaginal bleeding
  • IL-6
  • Intra-amniotic inflammation
  • Prematurity
  • Preterm delivery
  • Preterm labor

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