TY - JOUR
T1 - The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding
T2 - An unexpected observation
AU - Madan, Ichchha
AU - Romero, Roberto
AU - Kusanovic, Juan Pedro
AU - Mittal, Pooja
AU - Chaiworapongsa, Tinnakorn
AU - Dong, Zhong
AU - Mazaki-Tovi, Shali
AU - Vaisbuch, Edi
AU - Savasan, Zeynep Alpay
AU - Yeo, L.
AU - Kim, Chong Jai
AU - Hassan, Sonia S.
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Objective: Idiopathic vaginal bleeding, a common complication of pregnancy, increases the risk of small-for-gestational age (SGA) neonate, preeclampsia and preterm delivery and can be the only clinical manifestation of intra-amniotic infection and/or inflammation (IAI). Placenta previa is thought to be protective against ascending intrauterine infection, yet an excess of histologic chorioamnionitis has been reported in this condition. The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor. Study design: A retrospective cohort study including 35 women with placenta previa and vaginal bleeding <37 weeks of gestation who underwent amniocentesis was undertaken. Patients with multiple gestations were excluded. Intra-amniotic infection was defined as a positive culture for microorganisms, and intra-amniotic inflammation as an elevated amniotic fluid interleukin (IL)-6 concentration. IL-6 concentrations were determined by ELISA in 28 amniotic fluid samples available. Non-parametric statistics were used for analysis.
AB - Objective: Idiopathic vaginal bleeding, a common complication of pregnancy, increases the risk of small-for-gestational age (SGA) neonate, preeclampsia and preterm delivery and can be the only clinical manifestation of intra-amniotic infection and/or inflammation (IAI). Placenta previa is thought to be protective against ascending intrauterine infection, yet an excess of histologic chorioamnionitis has been reported in this condition. The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor. Study design: A retrospective cohort study including 35 women with placenta previa and vaginal bleeding <37 weeks of gestation who underwent amniocentesis was undertaken. Patients with multiple gestations were excluded. Intra-amniotic infection was defined as a positive culture for microorganisms, and intra-amniotic inflammation as an elevated amniotic fluid interleukin (IL)-6 concentration. IL-6 concentrations were determined by ELISA in 28 amniotic fluid samples available. Non-parametric statistics were used for analysis.
KW - Chorioamnionitis
KW - Cytokines
KW - Deciduitis
KW - Idiopathic vaginal bleeding
KW - IL-6
KW - Intra-amniotic inflammation
KW - Prematurity
KW - Preterm delivery
KW - Preterm labor
UR - http://www.scopus.com/inward/record.url?scp=77952143802&partnerID=8YFLogxK
U2 - 10.1515/JPM.2010.001
DO - 10.1515/JPM.2010.001
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C2 - 20146660
AN - SCOPUS:77952143802
SN - 0300-5577
VL - 38
SP - 275
EP - 279
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
IS - 3
ER -