TY - JOUR
T1 - The function of MITF and associated proteins in mast cells
AU - Nechushtan, Hovav
AU - Razin, Ehud
PY - 2002
Y1 - 2002
N2 - Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened with a construct that encodes the basic helix-loop-helix leucine zipper (bHLH-Zip) domain of MITF, resulted in the isolation of the protein kinase C interacting (PKCI) protein 1 and protein inhibitor of activated STAT3 (PIAS3). We have accumulated clear evidence of a function for these two proteins as repressors of MITF-induced transcriptional activity. Here, we describe this evidence and ideas that give some insight into the cellular network of interactions between various transcription factors and MITF.
AB - Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened with a construct that encodes the basic helix-loop-helix leucine zipper (bHLH-Zip) domain of MITF, resulted in the isolation of the protein kinase C interacting (PKCI) protein 1 and protein inhibitor of activated STAT3 (PIAS3). We have accumulated clear evidence of a function for these two proteins as repressors of MITF-induced transcriptional activity. Here, we describe this evidence and ideas that give some insight into the cellular network of interactions between various transcription factors and MITF.
KW - Mast cells
KW - Melanocytes
KW - MITF
KW - PIAS3
KW - PKCI
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=0036034250&partnerID=8YFLogxK
U2 - 10.1016/S0161-5890(02)00059-7
DO - 10.1016/S0161-5890(02)00059-7
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C2 - 12217380
AN - SCOPUS:0036034250
SN - 0161-5890
VL - 38
SP - 1177
EP - 1180
JO - Molecular Immunology
JF - Molecular Immunology
IS - 16-18
ER -