TY - JOUR
T1 - The functional role of Nudt2 in human triple negative breast cancer
AU - Abu-Rahmah, Rasha
AU - Nechushtan, Hovav
AU - Hidmi, Sanaa
AU - Meirovitz, Amichay
AU - Razin, Ehud
AU - Peretz, Tamar
N1 - Publisher Copyright:
Copyright © 2024 Abu-Rahmah, Nechushtan, Hidmi, Meirovitz, Razin and Peretz.
PY - 2024
Y1 - 2024
N2 - The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.
AB - The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.
KW - Anchorage-independent growth
KW - invasion
KW - migration
KW - NUDT2
KW - triple negative breast cancer (TNBC)
UR - http://www.scopus.com/inward/record.url?scp=85192167464&partnerID=8YFLogxK
U2 - 10.3389/fonc.2024.1364663
DO - 10.3389/fonc.2024.1364663
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C2 - 38715773
AN - SCOPUS:85192167464
SN - 2234-943X
VL - 14
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1364663
ER -
