The fusogen EFF-I controls sculpting of mechanosensory dendrites

Meital Oren-Suissa; David H. Hall; Millet Treinin; Gidi Shemer; Benjamin Podbilewicz

doi:10.1126/science.1189095

The fusogen EFF-I controls sculpting of mechanosensory dendrites

Meital Oren-Suissa, David H. Hall, Millet Treinin, Gidi Shemer^*, Benjamin Podbilewicz

^*Corresponding author for this work

Department of Medical Neurobiology

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

Original language	English
Pages (from-to)	1285-1288
Number of pages	4
Journal	Science
Volume	328
Issue number	5983
DOIs	https://doi.org/10.1126/science.1189095
State	Published - 4 Jun 2010

Access to Document

10.1126/science.1189095

Cite this

@article{828407a3eb064f09a2ad52d20c0df719,

title = "The fusogen EFF-I controls sculpting of mechanosensory dendrites",

abstract = "The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call {"}menorahs.{"} We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.",

author = "Meital Oren-Suissa and Hall, {David H.} and Millet Treinin and Gidi Shemer and Benjamin Podbilewicz",

year = "2010",

month = jun,

day = "4",

doi = "10.1126/science.1189095",

language = "אנגלית",

volume = "328",

pages = "1285--1288",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5983",

}

TY - JOUR

T1 - The fusogen EFF-I controls sculpting of mechanosensory dendrites

AU - Oren-Suissa, Meital

AU - Hall, David H.

AU - Treinin, Millet

AU - Shemer, Gidi

AU - Podbilewicz, Benjamin

PY - 2010/6/4

Y1 - 2010/6/4

N2 - The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

AB - The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

UR - http://www.scopus.com/inward/record.url?scp=77953259258&partnerID=8YFLogxK

U2 - 10.1126/science.1189095

DO - 10.1126/science.1189095

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 20448153

AN - SCOPUS:77953259258

SN - 0036-8075

VL - 328

SP - 1285

EP - 1288

JO - Science

JF - Science

IS - 5983

ER -

The fusogen EFF-I controls sculpting of mechanosensory dendrites

Abstract

Access to Document

Other files and links

Fingerprint

Cite this