The fusogen EFF-I controls sculpting of mechanosensory dendrites

Meital Oren-Suissa; David H. Hall; Millet Treinin; Gidi Shemer; Benjamin Podbilewicz

doi:10.1126/science.1189095

The fusogen EFF-I controls sculpting of mechanosensory dendrites

Meital Oren-Suissa
, David H. Hall
, Millet Treinin
, Gidi Shemer^*
, Benjamin Podbilewicz

^*Corresponding author for this work

Department of Medical Neurobiology

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

Original language	English
Pages (from-to)	1285-1288
Number of pages	4
Journal	Science
Volume	328
Issue number	5983
DOIs	https://doi.org/10.1126/science.1189095
State	Published - 4 Jun 2010

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abstract = "The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call {"}menorahs.{"} We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.",

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AU - Oren-Suissa, Meital

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AU - Shemer, Gidi

AU - Podbilewicz, Benjamin

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The fusogen EFF-I controls sculpting of mechanosensory dendrites

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