The glial framework reveals white matter fiber architecture in human and primate brains

Roey Schurr*, Aviv A. Mezer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Uncovering the architecture of white matter axons is fundamental to the study of brain networks. We developed a method for quantifying axonal orientations at a resolution of ~15 micrometers. This method is based on the common Nissl staining technique for postmortem histological slices. Nissl staining reveals the spatial organization of glial cells along axons. Using structure tensor analysis, we leveraged this patterned organization to uncover local axonal orientation. We used Nissl-based structure tensor analysis to extract fine details of axonal architecture and demonstrated its applicability in multiple datasets of humans and nonhuman primates. Nissl-based structure tensor analysis can be used to compare fine-grained features of axonal architecture across species and is widely applicable to existing datasets.

Original languageAmerican English
Article numberA34
JournalScience
Volume374
Issue number6568
DOIs
StatePublished - 5 Nov 2021

Bibliographical note

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© 2021 American Association for the Advancement of Science. All rights reserved.

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