The history and promising future of phage therapy in the military service

Daniel Gelman, Arik Eisenkraft, Nina Chanishvili, Dean Nachman, Shunit Coppenhagem Glazer, Ronen Hazan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The continuous evolvement of bacterial resistance to most, if not all, available antibiotics is a worldwide problem. These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infective modalities. One of the leading directions is phage therapy, which includes the administration of bacteriophages, viruses that specifically target bacteria, as biotherapies. Although neglected in the West until recent years, bacteriophages have been widely studied and clinically administered in the former Soviet Union and Eastern Europe for over a century, where they were found to be incredibly efficient at battling numerous infectious diseases. In this review, we discuss the high potential of phage therapy as a solution for resistant bacterial infectious diseases relating to military medicine. By describing the historical development and knowledge acquired on phage therapy, we define the advantages of bacteriophages for combating resistant bacteria in multiple settings, such as trauma injuries and foodborne illnesses, as a preventive tool and therapy against biological warfare agents, and more. We also present the most recent successful clinical applications of bacteriophages in military settings worldwide. We believe that augmenting military medicine by integrating phage therapy is an important and required step in preparedness for the rapidly approaching post–antibiotic era.

Original languageAmerican English
Pages (from-to)S18-S26
JournalJournal of Trauma and Acute Care Surgery
Volume85
Issue number1 S
DOIs
StatePublished - 1 Jul 2018

Bibliographical note

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Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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