The Human Chronic Pain Phenome: Mapping Nongenetic Modifiers of the Heritable Risk

Ze'ev Seltzer*, Scott R. Diehl, Hance Clarke, Joel Katz

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

This chapter is dedicated to chronic neuropathic pain, the most perplexing pain condition. This disorder is used as an example to illustrate how nature and nurture interact to produce pain as well as to better understand the inter-individual variability in chronic pain. Growing data from the Human Genome Project, and its application to pain research, indicate that a comprehensive assessment of the phenomic and genomic risk and protective factors of pain will provide knowledge critically needed when clinicians administer personalized pain management. The chapter explains the modification of the heritable risk for CNP by certain personality traits. It is generally accepted that personality, like pain, is a collection of complex traits controlled by genetic and nongenetic determinants. The chapter illustrates a number of nongenetic factors and suggests future clinical research studies that appear promising based on findings in animal models of painful neuropathies.

Original languageEnglish
Title of host publicationPain Genetics
Subtitle of host publicationBasic to Translational Science
PublisherWiley-Blackwell
Pages161-182
Number of pages22
ISBN (Electronic)9781118398890
ISBN (Print)9781118398845
DOIs
StatePublished - 25 Nov 2013
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 John Wiley & Sons, Inc.

Keywords

  • Chronic neuropathic pain (CNP)
  • Heritable risk
  • Human chronic pain phenome
  • Nongenetic modifiers
  • Pain medicine

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