The immunogenicity of human embryonic stem-derived cells

Micha Drukker*, Nissim Benvenisty

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

190 Scopus citations

Abstract

Human embryonic stem cells have excellent potential for being the ultimate source of transplantable cells for many different tissues. To enable their clinical use, differentiation protocols should be developed and safety standards must be met. The cells should improve symptoms without generating side effects and their immune rejection must be overcome. Profiling of the immune antigens expressed on the cells has revealed that upon differentiation the cells express molecules of the major histocompatibility complex. Here, we propose ways of overcoming the rejection of human embryonic stem cells after transplantation.

Original languageAmerican English
Pages (from-to)136-141
Number of pages6
JournalTrends in Biotechnology
Volume22
Issue number3
DOIs
StatePublished - Mar 2004

Bibliographical note

Funding Information:
We thank the members of our laboratory for critical review of the manuscript. This research was partially supported by funds from the Herbert Cohn Chair (Hebrew University).

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