The Impact of Fast-food Diet on Bone Development, Metabolism and Quality

E Monsonego-Ornan, J Zaretsky, S Griess-Fishheimer, T Travinsky, R Shahar

Research output: Contribution to journalMeeting Abstractpeer-review


Endochondral ossification in the growth-plates provides a
narrow window of opportunity to achieve optimal bone size and
quality. Modern western diet has negative health implications;
however, its effects on skeleton development have not been explored. We show that young rats, fed exclusively with McDonald’s
meals suffer from growth retardation due to growth-plates lesions
within the tibiae. Bone mineral density decreased significantly,
structural parameters of trabecular and cortical bone deteriorated dramatically, as did the mechanical performances of the bones.
Supplementations with either multi-vitamins and minerals, or
calcium alone resulted in partial rescue of growth-plate and bone
phenotypes, but were accompanied by kidneys’ calcium deposits.
Our findings highlight for the first time, the severe pathology that
consuming a fast-food diet does to the skeleton of growing young
mammals. Pathologies that extends much beyond the known metabolic effects. These results are relevant to human’s health as human bone pathologies corresponds with the rats’ phenotypes, and
fast-food eating pattern is highly common among children around
the world
Original languageAmerican English
Pages (from-to)181-181
Number of pages1
JournalAnnals of Nutrition and Metabolism
StatePublished - 2017


  • Processed food
  • Chondrocytes
  • Cortical bone
  • Skeleton development


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