The incapability of lnterleukin-4 to induce AP-1 activity in murine mast cells

Ellen Chaikin, Imad Hakeem, Ehud Razin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3-and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume107
Issue number1-3
DOIs
StatePublished - 1995

Keywords

  • 4AP-1
  • Interleukin
  • Mast Cells

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